Acs Environmental Science And Technology Impact Factor – 228) C.P. West, D. Mesa Sanchez, A.C. Morales, Y.-J. Hsu, J Ryan, A. Darmody, L. Slipchenko, J. Laskin, A. Laskin. Molecular and structural characterization of isomeric compounds in atmospheric organic aerosols using tandem ion mobility-mass spectrometry.

221) CP West, J. Ryan, A.C. Morales, M.M. Misovich, A.P.S. Hettiyadura, F. Rivera-Adorno, J.M. Tomlin, A. Darmody, B.N. Linn, P. Lin, A. Laskin, right Molecular study of heterogeneous photochemistry of iron(III) citrate in aqueous solution. Environmental Science: Processes and Impacts, 25 190-213, (2022). No.: 10.1039/D1EM00503K

Acs Environmental Science And Technology Impact Factor

Acs Environmental Science And Technology Impact Factor

212) A.P.S. Khettiadulla, A. Ruskin. Quantitative analysis of polycyclic aromatic hydrocarbons using a high-performance liquid chromatography-photodiode array-high-resolution mass spectrometry detection platform coupled with electrospray and atmospheric pressure photoionization sources. Journal of Mass Spectrometry, 57(2), e4804, (2022). doi:10.1002/jms.4804 (Specially invited teaching article)

Pdf) Assessing The Efficacy Risk Of The Widely Used Chiral Glufosinate: Switch From The Racemate To The Single Enantiomer?

185) C. Li, Q. He, A. P. S. Hettiyadura, U. Käfer, G. Shmul, D. Median, R. Zimmermann, S.S. Brown, C. George, A. Laskin, Y. Rudich. Formation of secondary brown carbon in biomass burning aerosol agents via NO3 radical reactions. Environmental Science and Technology, 54, 1395−1405, (2020). doi:10.1021/acs.est.9b05641

164) Northwest Northeast May M. Olson, Panas, J.L. Axson, P.S. Tirrella, R.M. Copps, R.M. Craig, M.J. Gunsch, South China, A. Laskin , A.P. Ault, K.A. Pratt. Aerosol emissions from harmful algal blooms in the Great Lakes.

158) P. Lin, N. Bluvshtein, Y. Rudich, J. Laskin, A. Laskin. Molecular structure of atmospheric brown carbon inferred from biomass burning events across the country.

141) B. Wang,* D. A. Knopf, S. China, B. W. Arey, T. H. Harder, M. K. Gilles, A. Laskin. Detection of single ice nucleation events using environmental scanning electron microscopy.

Xing Wins A Best Paper Award From Environment, Society & Technology

131) ML Hinks, M.V. Brady, H. Lignell, M. Song, J. Grayson, A.K. Bertram, P. Lin, A. Ruskin, J. Ruskin, S.A. Niedzkorodov . Effects of temperature and relative humidity on the internal optics of secondary organic aerosol materials.

125) P. Lin, J. Liu, J.E. Shilling, S.M. Kesman, J. Raskin, A. Raskin. Molecular characterization of the brown carbon (BrC) chromophore in secondary organic aerosols produced by toluene photooxidation.

107) S. Gosar, P. Weber, A. Ruskin. Spatially resolved imaging of single atmospheric particles using nanoscale imaging mass spectrometry: insights into particle origin and structure.

Acs Environmental Science And Technology Impact Factor

97) J. Ruskin, A. Ruskin and S.A. Nizkorodov. New mass spectrometry techniques for studying the physical properties of particles, droplets and surfaces.

Research Spotlight: Mercury Exposure In Wild Songbirds (image)

95) H. Chen, V.H. Grassian, L.V. Saraf, A. Ruskin. Imaging analysis of environmental particles using focused ion beam/scanning electron microscopy: microscopic analytical insights into fly ash in the atmosphere.

94) T. B. Nguyen, S.A. Nizkorodov, A. Laskin, J. Laskin. Methods for the quantification of organic compounds in complex environmental samples using high-resolution electrospray ionization mass spectrometry.

91) J. Ruskin, P.A. Eckert, P.J. Roach, B.S. Heath, S.A. Nizkorodov, A. Ruskin analysis of complex organic mixtures using reactive nanospray desorption electrospray ionization mass spectrometry.

75) A. Bateman, S. Nizkorodov, J. Ruskin, A. Ruskin. Photoprocessing of secondary organic aerosols dissolved in cloud droplets.

Catalysis Science And Technology Journal

74) Internal structure, hygroscopicity and reaction of Y. Liu, B. Minofar, Y. Desyaterik, E. Dames, Z. Zhu, J.P. Cain, R. J. Hopkins, M. K. Gilles, H. Wang, P. Jungwirth, A. Laskin Sexually mixed sodium methanesulfonate-sodium chloride granules.

59) J.P. Kane, P.L. Gassman, H. Wang, A. Laskin Microscopic FTIR study of soot composition – Evidence for aliphatic hydrocarbons on the surface of nascent soot. 4. Factors determining susceptibility of fish to human drug effects, environment. science. technology. 2023 Krisna Marty, Andrew Ross Brown, Anke Lange, and Charles R. Taylor

The increasing levels and frequency of detection of active pharmaceutical ingredients (APIs) in the environment is a cause for serious concern, particularly given the potential adverse effects they may have on non-target species such as fish. As many pharmaceuticals lack environmental risk assessments, there is a need to better define and understand the potential risks to fish posed by APIs and their biotransformation products, while still minimizing the use of experimental animals. Extrinsic (environmental and drug-related) and intrinsic (fish-related) factors make fish potentially susceptible to the effects of human drugs, but these factors are not necessarily captured in non-fish tests. This critical review explores these factors, with a particular focus on the unique physiological processes of drug absorption, distribution, metabolism, excretion, and toxicity (ADMET) in fish. Highlights include the impact of fish life stage and species on multi-pathway drug absorption (A); the potential impact of fish’s unique blood pH and plasma composition on systemic distribution of drug molecules (D); the endothermic properties of fish and their How the differential expression and activity of drug-metabolizing enzymes in tissues affects drug metabolism (M); and how their unique physiology affects the relative contribution of different excretory organs to API and metabolite excretion (E). These discussions provide insight into existing drug characterization, pharmacokinetic, and pharmacodynamic data from mammalian and clinical studies that may or may not be useful in understanding the environmental risks of fish APIs.

Acs Environmental Science And Technology Impact Factor

3. Minimizing experimental testing of traditional medicines on fish, Environ. science. technology. 2023 Anya Cools, A. Rose Brown, Samuel K. Maynard, Alison Nimrod Perkins, Stuart Owen, Charles R. Taylor

Devmita Chakraborty On Linkedin: Acs Premium Science Journals

Prior to 2006, there were no regulatory requirements authorizing ecotoxicological testing of human drugs, many of which had little or no data available to assess their environmental risks. Due to animal welfare considerations, we developed a decision tree to minimize in vivo fish testing of such traditional active pharmaceutical ingredients (APIs). The lowest no observed effect concentration (NOEC

, the lowest NOEC in chronic Daphnia and algal toxicity studies), Theoretical Treatment Water Concentration (TWC, calculated using a fish plasma model) and Predicted Environmental Concentration (PEC) were used to derive the API risk quotient (PEC/NOEC)

And PEC/TWC). Based on a validation data set of 96 APIs, we show that by setting the threshold for both risk quotients at 0.001, the need for in vivo fish testing may be reduced by approximately 35% without reducing the level of environmental protection. Therefore, for most APIs, an evaluation factor of 1000 is applied to the NOEC (equivalent to a threshold of 0.001)

, TWC provides an effective safety net for others. In silico and in vitro data, as well as mammalian toxicity data, may further support a final decision on the need for fish testing.

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2. Greener pharmaceuticals to achieve more sustainable healthcare and environment. science. technology. Wright. 2022 Caroline T. A. Mormond, Neil Pullman, Stewart F. Owen, Jim Ryan, Jason Schneib, Bastian J. Vincius , Klaus Kummerer

Pharmaceuticals are critical to human health, but they can also affect aquatic and terrestrial environments when used by patients, and can be released into wastewater through excrement. We emphasize the need for a greener approach to identifying and meeting important environmental standards, which will help reduce the environmental impact of pharmaceutical residues. These criteria include reduction of impacts by avoiding non-target effects or undesirable parts, reduction of exposure by reducing emissions or environmental (bio)degradability, absence of PBT (persistent, bioaccumulative and toxic) substances, and risk mitigation. However, according to all these criteria, the health of the patient is of paramount importance, as the drug must be safe and effective in treating the disease. We discuss the feasibility of incorporating these green design active pharmaceutical ingredient standards into the drug discovery and development process and what tools or analyzes are needed to achieve this goal. The integrated GREENER approach can be used to accelerate discussions about future innovations in drug discovery and development.

1. Fish generalized physiological dynamics model for environmental risk assessment of pharmaceuticals, Environ. science. technology. 2022 Jiaqi Wang, Tom M. Nolte, Stewart F. Owen, Rémy Beaudouin, A. Jan Hendriks, and Ad M.J. Ragas

Acs Environmental Science And Technology Impact Factor

An increasing number of pharmaceuticals found in the environment may have adverse effects on organisms such as fish. Physiology-based kinetic (PBK) models are important risk assessment tools that enable a mechanistic approach to understanding chemical effects in organisms. However, fish PBK models are limited to a few species, limiting their overall applicability to countless species. Furthermore, many drugs are ionizable, and fish PBK models that account for ionization are rare. Here, we develop a generalized PBK model that estimates the required parameters as a function of fish and chemical properties. We evaluated model performance for five drugs (covering neutral and ionic structures). Using EPI Suite’s biotransition half-life (HL), 73% and 41% of time course estimates were within 10- and 3-fold of the measured values, respectively. HL performance improved using experimental biotransformation (87% and 59%, respectively). Estimates of ionizable species are more accurate than any existing species-specific PBK model. This study is the first to develop a generalized fish PBK model focusing on mechanism-based parameterization and explicitly considering ionization. Our general model facilitates its application across chemicals and species, improves the efficiency of environmental risk assessment and supports animal-free toxicity testing paradigms.

Chemistry Articles Everyone Was Reading In April 2023

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